After installation, there will be a "CutePDF Writer" printer installed. What you need to do is just print out your Word/Excel/gif through this printer. And the software will prompt you for the location of pdf file.
There is additional printer option for you to set attribute of target pdf file. If you have large size image in your document, you can try to use these options to compress the pdf file. The generation time for the pdf file would be longer if these option are turned on.
URL: www.cutepdf.com/Products/CutePDF/writer.asp